Our Mission

The overall goal of our biologics department is to develop strategies that enhance the integration and long term functionality of surgical repair methods, implants, and grafts when introduced into the body. We have adopted a systematic empirically driven approach to guide design processes in accomplishing this goal.

Biologics Research

“Our systematic, multi-faceted approach cost-effectively identifies materials, geometries, and coatings that promote repair and implant incorporation into multiple tissue types.”

Design & Testing of Tissue In Growth Strategies

Complete in silico FEA hip model

Complete in silico FEA hip model

Initial Fixation
In addition to biocompatibility and cellular response testing, we utilize cadaveric, computer, and surrogate models to ascertain the adequacy of an implant, graft, or particular repair technique in providing initial fixation and the mechanical environment necessary for healing.

Ex vivo Modeling
A perfusion flow organ culture method that employs modular dynamic loading bioreactor systems is used to isolate factors or features that contribute to tissue interface integration and long term incorporation. This system maintains a physiologic environment while inducing prescribed biomechanical loads to study the effect of systematic changes made to the implants structure, surface, or composition. The empirical data gathered from these tests directs design processes at a reduced cost to animal studies.

Validated acetabulum surrogate model for THR design. Chondrocyte outgrowth

Validated Acetabulum Surrogate Model for THR Design

Chondrocyte outgrowth